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In Europe, pre-Socratics speculated the underlying nature of the visible world. Thales (c. 624 BC–c. 546 BC) regarded water as the fundamental material of the world. Anaximander (c. 610 BC–c. 546 BC) posited that the basic material was wholly characterless or limitless: the Infinite (apeiron). Anaximenes (flourished 585 BC, d. 528 BC) posited that the basic stuff was pneuma or air. Heraclitus (c. 535–c. 475 BC) seems to say the basic element is fire, Cược Trực Tuyến though perhaps he means that all is change. Empedocles (c. 490–430 BC) spoke of four elements of which everything was made: earth, water, air, and fire.[65] Meanwhile, Parmenides argued that change does not exist, and Democritus argued that everything is composed of minuscule, inert bodies of all shapes called atoms, a philosophy called atomism. All of these notions had deep philosophical problems.[66]